Infectious Diseases; Molecular Mechanisms of Haemophilus Influenzae Pathogenesis
Pathogenesis, epidemiology, vaccine testing components. Malaria
Regulation of bacterial virulence and the development of strategies to disrupt bacterial infections in cystic fibrosis (CF)
Hepatitis C Virus
Elucidating the virus-cell interactions involved in the assembly and the entry of retroviruses
Immunopathogenesis of malaria infections with a view to the development of vaccines and novel adjunct therapies for malaria
Tuberculosis/bacterial pathogenesis/immunity to infection
HIV assembly, host restriction factors that limit HIV replication, and the development of Novel HIV vaccines.
Genetic basis and regulation of bacterial virulence components; Innate immunity; Vaccines
Research in our lab focuses on how host cells detect, respond, and regulate immunity to viral infection. In particular, we are interested in how pattern recognition receptors, like the RIG-I like receptors, regulate innate immune, humoral, and cell-mediated responses during virus infection.
Mechanisms of bacterial pathogenesis
Structural biology, cryo-electorn microscopy, bacterial structure, and regulation of virus assembly