Immunology and pathogenesis of chronic viral infections; immunological memory and vaccine development.
T-Cell immune responses to HIV infection, vaccine development, and development of T-Cell memory
HIV Vaccines, therapy and pathogenesis
Genetic and epigenetic regulation of immune system genes
Transmissible antibody resistance and pathogenesis of group A streptococcus; mechanisms of transposition.
Cellular immunity and mechanisms of immune regulation in human Mycobacterium tuberculosis infection and HIV co-infection.
T-cell recognition of peptide:MHC antigens; autoimmunity; role of SHP-1 phosphatase.
In situ analysis of B and T cell memory.
The mucosal surfaces of the respiratory, intestinal, and genital tracts are primary portals of entry for a wide range of pathogens.
Transmission of influenza virus from host to host and reassortment of influenza virus gene segments
Research in our laboratory centers on the emerging pathogen, Clostridium difficile. C. difficile causes chronic intestinal disease that is both difficult and costly to treat.
Replication and pathogenesis of the cytomegaloviruses, including latency, host modulation and host response to infection.
Bacterial development; microbial genetics; gene expression during bacterial differentiation, RNA polymerase-promoter interactions and regulation of gene transcription.
Regulation of gene expression in Acinetobacter baumannii and Proteus mirabilis.
Genetics of antibiotic resistance; antimicrobial peptides; transcriptional regulation of gene expression; mechanisms of bacterial pathogenesis.
Pathogenesis of gamma-herpesviruses and development of lymphoma and other cancers.
Development of influenza virus vaccines; elucidation of molecular determinants of influenza virus transmission
Emerging infectious diseases, and molecular biology and genetics