The immune system provides defense against microorganisms and cancer, achieving this protection through both cellular and molecular mechanisms that are innate and/or adaptive. Elucidating these mechanisms provides critical guides to the rational development of immunotherapies and vaccines. Researchers in our department use state-of-the-art approaches and models to investigate how the immune system responds to viral and bacterial infections, as well as how failures of immune tolerance can cause autoimmune disease. Through these efforts, strategies to combat disease and develop novel treatments for autoimmunity are being developed.
Areas of interest include: mechanisms of antigen presentation and gene regulation; T cell and B cell differentiation and the development of immune memory; mechanisms of autoimmunity; and mechanisms of immune response to microorganisms.