Assistant Professor of Pediatrics
Department of Pediatric Infectious Diseases
Rollins Research Center
1510 Clifton Rd, Suite 3108
Atlanta, GA 30322
The Lamb Lab focuses on understanding the immunopathogenesis of malaria infections with a view to the development of vaccines and novel adjunct therapies for malaria. Malaria is generally associated with an inflammatory response characterized by the expansion of CD4+ Th1 cells that produce interferon-gamma, as well as the activation of CD8+ T cells. This response activates immunological mechanisms to clear malaria parasites from the body but, when over-exuberant, also contributes to the pathogenesis of malaria infection. We are undertaking several projects to understand the factors that shape the inflammatory T cell response in malaria infection. Currently we are focused on understanding the role of Eph receptors, the largest family of receptor tyrosine kinases, in T cell responses to malaria. In collaboration with Sam Speck's lab, we are also defining the immunological interactions that occur during co-infection with gamma herpes viruses and malaria with a view to understanding the impact of Epstein-Barr virus infection on the response of T follicular helper cells during malaria infection. I am a member of the NIH-funded MaHPIC team led by Dr Mary Galinski in which we are undertaking a systems biology approach to understanding malaria infections of non-human primates as a model for host-pathogen interactions.