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Tracey J. Lamb

Assistant Professor of Pediatrics
Department of Pediatric Infectious Diseases

Phone: 404-712-7883

Fax: 404-727-9923


Mailing Address:
Rollins Research Center
1510 Clifton Rd, Suite 3108
Atlanta, GA 30322

The Lamb Lab focuses on understanding the immunopathogenesis of malaria infections with a view to the development of vaccines and novel adjunct therapies for malaria. Malaria is generally associated with an inflammatory response characterized by the expansion of CD4+ Th1 cells that produce interferon-gamma, as well as the activation of CD8+ T cells. This response activates immunological mechanisms to clear malaria parasites from the body but, when over-exuberant, also contributes to the pathogenesis of malaria infection. We are undertaking several projects to understand the factors that shape the inflammatory T cell response in malaria infection. Currently we are focused on understanding the role of Eph receptors, the largest family of receptor tyrosine kinases, in T cell responses to malaria. In collaboration with Sam Speck's lab, we are also defining the immunological interactions that occur during co-infection with gamma herpes viruses and malaria with a view to understanding the impact of Epstein-Barr virus infection on the response of T follicular helper cells during malaria infection. I am a member of the NIH-funded MaHPIC team led by Dr Mary Galinski in which we are undertaking a systems biology approach to understanding malaria infections of non-human primates as a model for host-pathogen interactions.

Research Topics